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Jeho otec Alexander Sidon pocházel z Trnavy, kde působil jako rabín jeho prastrýc Šimon Sidon. Po studiu scenáristiky na FAMU pracoval Karol Sidon v Českém rozhlase, po podpisu Charty 77 byl zaměstnán jako topič. Roku 1978 obdržel exilovou cenu Jiřího Koláře za román <i>Boží osten</i>, následoval románový esej <i>Evangelium podle Josefa Flavia</i>. Osud rodiny přispěl k tomu, že dospělosti (1978) přijal židovskou víru. V roce 1983 byl nucen pod nátlakem StB emigrovat do Německa, kde vystudoval judaistiku a rabínská studia dokončil v Izraeli. V roce 1992 se stal vrchním zemským rabínem. V roce 2012 vyšel jeho překlad Pěti knih Mojžíšových v česko-hebrejském vydání. S Karlem Hvížďalou vydali několik knih rozhovorů.  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