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Působí na 3. lékařské fakultě Univerzity Karlovy, kde byl po revoluci v roce 1989 prvním svobodně zvoleným děkanem a 30 let přednostou Kliniky psychiatrie a lékařské psychologie. Je zakladatelem a dlouholetým bývalým ředitelem Národního ústavu duševního zdraví v Klecanech, dříve Psychiatrického centra Praha. Zabývá se především biologickou psychiatrií, psychofarmakologií a psychoneuroendokrinologií. Je autorem mnoha odborných i popularizujících knih a článků o duševním zdraví i společenských otázkách. Byl prezidentem Evropské psychiatrické asociace (EPA, 2007–2008) a Federace evropských lékařských akademií (FEAM, 2008–2009). Je zakládajícím členem Učené společnosti ČR a nositelem ocenění Česká hlava (2008). V roce 2023 obdržel Cenu Arnošta Lustiga za odvahu a statečnost, lidskost a spravedlnost. 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